How do we improve histone deacetylase inhibitor drug discovery?
نویسندگان
چکیده
منابع مشابه
Hybrid Polar Histone Deacetylase Inhibitor Induces Apoptosis
Inhibitors of histone deacetylase (HDAC) have been shown to have both apoptotic and differentiating effects on various tumor cells. M-carboxycinnamic acid bishydroxamide (CBHA) is a recently developed hybrid polar compound structurally related to hexamethylene bisacetamide. CBHA is a potent inhibitor of HDAC activity. CBHA induces cellular growth arrest and differentiation in model tumor system...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Discovery
سال: 2020
ISSN: 1746-0441,1746-045X
DOI: 10.1080/17460441.2020.1736032